Thermo Fisher Scientific TDP-43 Polyclonal Antibody
TDP-43 단백질을 인식하는 염소 유래 polyclonal 항체로, Western blot에 최적화되어 있습니다. 인간 단백질에 반응하며, 다른 종에서도 예측 반응성을 보입니다. 액상 형태로 제공되며, 0.5 mg/mL 농도로 공급됩니다. 연구용으로만 사용 가능합니다.
- 카탈로그번호
- PA519064
- 판매단위
- pk
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Applications
Western Blot (WB)
- Tested Dilution: 0.3–1 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Goat / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide sequence (HISNAEPKHNSNRQ) corresponding to the internal amino acids of TARDBP (aa 256–270) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Ammonium sulfate precipitation |
| Storage Buffer | TBS, pH 7.3, with 0.5% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_10984613 |
Product Specific Information
- Predicted to react with bovine, canine, porcine, and rat based on sequence homology.
- Tested in Peptide ELISA: antibody detection limit dilution 16,000.
Target Information
TDP43 was first identified as a novel cellular protein that binds to HIV-1 TAR DNA sequence motifs and acts as a transcriptional repressor to the HIV-1 LTR. It also regulates splicing of exon 9 of the cystic fibrosis transmembrane conductance regulator (CFTR), likely through association with UG repeats at the 3′ splice site.
A hyperphosphorylated, ubiquitinated, and cleaved form of TDP43, known as pathologic TDP43, is the major disease protein in ubiquitin-positive, tau-, and alpha-synuclein-negative frontotemporal dementia (FLTD-U).
TDP43 is distinct from TRBP1, an RNA-binding protein that binds HIV-1 TAR RNA sequences.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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