Thermo Fisher Scientific TDP-43 Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 0.3–1 µg/mL

Product Specifications

Product Specific Information

• Predicted to react with bovine, canine, porcine, and rat based on sequence homology.
• Tested in Peptide ELISA: antibody detection limit dilution 16,000.

Target Information

TDP43 was first identified as a novel cellular protein that binds to HIV-1 TAR DNA sequence motifs and acts as a transcriptional repressor to the HIV-1 LTR. It also regulates splicing of exon 9 of the cystic fibrosis transmembrane conductance regulator (CFTR), likely through association with UG repeats at the 3′ splice site.
A hyperphosphorylated, ubiquitinated, and cleaved form of TDP43, known as pathologic TDP43, is the major disease protein in ubiquitin-positive, tau-, and alpha-synuclein-negative frontotemporal dementia (FLTD-U).
TDP43 is distinct from TRBP1, an RNA-binding protein that binds HIV-1 TAR RNA sequences.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.