Thermo Fisher Scientific Estrogen Receptor alpha Polyclonal Antibody, FITC
에스트로겐 수용체 알파(FITC 결합) 폴리클로날 항체로 인간, 마우스 등 다양한 종에 반응. WB, IHC, ELISA, IP에 사용 가능. 고순도 친화 크로마토그래피 정제 및 안정적 저장 버퍼 구성. 연구용으로만 사용.
- 카탈로그번호
- ESTRA-121-FITC
- 판매단위
- pk
카탈로그
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunohistochemistry (IHC) | 1:50–1:250 |
| ELISA | 1:10,000 |
| Immunoprecipitation (IP) | 1:50–1:250 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Non-human primate, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide within amino acid region 545–595 on human Estrogen receptor alpha protein |
| Conjugate | FITC |
| Excitation / Emission Max | 498 / 517 nm |
| Form | Liquid |
| Concentration | 0.5–1.5 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | Proprietary buffer, pH 7.4–7.8, with 30% glycerol and 0.5% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, store in dark |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Estrogen Receptors (ER) belong to the steroid/thyroid hormone receptor superfamily of nuclear receptors. The estrogen receptor acts as a ligand-activated transcription factor that, upon binding to estrogen, undergoes conformational change enabling dimerization and interaction with estrogen response elements (ERE) in DNA. This binding regulates gene transcription by recruiting coactivator or corepressor proteins.
Two forms of the estrogen receptor exist—alpha and beta—encoded by separate genes (ESR1 and ESR2). Alternative RNA splicing produces at least four known estrogen receptor-alpha isoforms (66 kDa, 53 kDa, 47 kDa, 35 kDa). Estrogen receptors are widely expressed and crucial for sexual development and reproductive function, as well as roles in bone and other tissues. They are implicated in diseases such as breast cancer, endometrial cancer, and osteoporosis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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