Thermo Fisher Scientific Estrogen Receptor alpha Polyclonal Antibody, FITC
에스트로겐 수용체 알파(ERα)를 인식하는 FITC 결합 폴리클로날 항체. Western blot, ELISA, IP에 사용 가능. 사람 및 랫드 반응성. 액상 형태로 -20°C 보관, 암조건 유지. 연구용으로만 사용.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| ELISA | 1:10,000 |
| Immunoprecipitation (IP) | 1:50–1:250 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide within amino acid region 30–80 on human ESTRA protein |
| Conjugate | FITC (Fluorescein) |
| Excitation / Emission Max | 498 / 517 nm |
| Form | Liquid |
| Concentration | 0.5–1.5 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | Proprietary buffer, pH 7.4–7.8, with 0.5% BSA, 30% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | –20°C, store in dark |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Estrogen Receptors (ER) are members of the steroid/thyroid hormone receptor superfamily of nuclear receptors. The estrogen receptor is a ligand-activated transcription factor that, when bound to estrogen hormone, induces a conformational change allowing dimerization and binding to estrogen response elements (ERE) in DNA. ER regulates gene transcription through coactivator or corepressor recruitment.
There are two forms of the estrogen receptor, alpha (ESR1) and beta (ESR2), encoded by separate genes. At least four alpha isoforms are known (66 kDa, 53 kDa, 47 kDa, 35 kDa). Estrogen receptors are essential for sexual development, reproductive function, and play roles in tissues such as bone. They are implicated in diseases including breast cancer, endometrial cancer, and osteoporosis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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