Thermo Fisher Scientific Phospho-BRCA1 (Ser1387) Polyclonal Antibody
BRCA1 단백질의 Ser1387 인산화 형태를 특이적으로 인식하는 Rabbit Polyclonal 항체. Western blot과 IHC(파라핀 절편)에 적합. Human, Mouse, Rat 시료에 반응. 고순도 정제 및 1 mg/mL 농도, -20°C 보관.
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Applications
Western Blot (WB)
- Tested Dilution: 1:1,000–1:3,000
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:50–1:200
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human BRCA1 (Accession P38398), corresponding to amino acid residues around phosphorylated Ser1387. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2817330 |
Product Specific Information
This antibody detects endogenous levels of BRCA1 only when phosphorylated at Ser1387.
Target Information
BRCA1 (breast and ovarian cancer susceptibility protein 1) is a nuclear phosphoprotein involved in maintaining genomic stability and acts as a tumor suppressor. It forms part of the BASC (BRCA1-associated genome surveillance complex) with other DNA damage sensors and signal transducers. BRCA1 associates with RNA polymerase II and histone deacetylase complexes, contributing to transcription regulation and DNA double-strand break repair.
Mutations in BRCA1 are linked to approximately 40% of inherited breast cancers and over 80% of inherited breast and ovarian cancers. Multiple alternatively spliced variants exist, some associated with disease. A related pseudogene is also located on chromosome 17.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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