Thermo Fisher Scientific Phospho-Ask1 (Thr838) Recombinant Rabbit Monoclonal Antibody (Ask1T838-8D12)
Phospho-Ask1 (Thr838) 특이성을 가진 재조합 토끼 단클론 항체로, 인간 및 마우스 시료에서 사용 가능. HEK293 세포에서 발현되었으며 Protein A/G로 정제됨. Flow Cytometry에 적합하며 다양한 형광 접합 형식으로 제공됨. 연구용으로만 사용.
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Applications
Flow Cytometry (Flow)
- Tested Dilution: 1–1,000 ng/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG, kappa |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | Ask1T838-8D12 |
| Immunogen | A synthetic phospho-peptide corresponding to residues surrounding Thr838 of human phospho Ask1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS with 50% glycerol, 0.10% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2897119 |
Additional Formats
Target Information
MAP3K5 (ASK1) is a serine/threonine kinase abundantly expressed in human heart and pancreas. It is activated in response to cytokines, growth factors, and environmental stresses. ASK1 (apoptosis signal-regulating kinase 1) activates MKK4 and MKK6, which in turn activate JNK and p38 MAP kinases. ASK1/MAPKKK5 is activated by TNFR and Fas through interactions with TRAF family members and Daxx. Overexpression of ASK1 induces apoptotic cell death, while its inactive form inhibits TNF-α-induced apoptosis. ASK1 is expressed in various human and mouse tissues.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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