Thermo Fisher Scientific Phospho-Ask1 (Thr838) Recombinant Rabbit Monoclonal Antibody (Ask1T838-8D12), FITC
인간 및 생쥐 ASK1 단백질의 Thr838 인산화 부위를 표적하는 FITC 결합 재조합 토끼 단클론 항체입니다. Flow Cytometry에 적합하며, 고순도 Protein A/G 정제 및 PBS-BSA 완충액에 보관됩니다. 4°C 암소 저장, 연구용 전용 시약입니다.
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Thermo Fisher Scientific Phospho-Ask1 (Thr838) Recombinant Rabbit Monoclonal Antibody (Ask1T838-8D12), FITC
Applications
- Flow Cytometry (Flow): 5 µL / 1×10⁶ cells
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG, kappa |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | Ask1T838-8D12 |
| Immunogen | A synthetic phospho-peptide corresponding to residues surrounding Thr838 of human phospho Ask1 |
| Conjugate | FITC |
| Excitation / Emission Max | 498 / 517 nm |
| Form | Liquid |
| Purification | Protein A/G |
| Storage Buffer | PBS with 0.20% BSA |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C, store in dark |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2897121 |
Additional Formats
Target Information
MAP3K5 (ASK1) is a serine/threonine kinase abundantly expressed in human heart and pancreas. It is activated by various extracellular stimuli such as cytokines, growth factors, and environmental stresses. ASK1 (apoptosis signal-regulating kinase 1) activates MAPKKs MKK4 and MKK6, which in turn activate JNK and p38 MAP kinases. ASK1 is activated by TNFR and Fas through interactions with TRAF family members and Daxx. Overexpression induces apoptosis, while inactive forms inhibit TNF-α–induced apoptosis. ASK1 is expressed in various human and mouse tissues.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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