Thermo Fisher Scientific Phospho-Ask1 (Thr838) Recombinant Rabbit Monoclonal Antibody (Ask1T838-8D12), APC
인간 및 생쥐 ASK1 단백질의 Thr838 인산화 부위를 특이적으로 인식하는 재조합 단일클론 항체입니다. APC 형광체로 결합되어 유세포분석(Flow Cytometry)에 적합합니다. 고순도의 Protein A/G 정제 항체로 안정적인 신호 검출이 가능합니다.
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Applications
- Flow Cytometry (Flow): 5 µL/1×10⁶ cells
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG, kappa |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | Ask1T838-8D12 |
| Immunogen | A synthetic phospho-peptide corresponding to residues surrounding Thr838 of human phospho Ask1 |
| Conjugate | APC |
| Excitation / Emission Max | 651 / 660 nm |
| Form | Liquid |
| Purification | Protein A/G |
| Storage Buffer | PBS with 0.20% BSA |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2897122 |
Additional Formats
Target Information
MAP3K5 (ASK1) is a serine/threonine kinase abundantly expressed in human heart and pancreas. It is activated by various extracellular stimuli such as cytokines, growth factors, and environmental stresses. ASK1 activates MKK4 and MKK6, which in turn activate JNK and p38 MAP kinases. ASK1/MAPKKK5 is activated by TNFR and Fas through interaction with TRAF family members and Daxx. Overexpression of ASK1 induces apoptosis, while catalytically inactive ASK1 inhibits TNF-α-induced apoptosis. ASK1 is expressed in various human and mouse tissues.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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