Thermo Fisher Scientific ATRX Monoclonal Antibody (2-E7)
마우스 유래 모노클로날 항체로 ATRX 단백질 검출에 사용. IHC(P) 및 ICC/IF에 1:200 희석으로 적합. Protein G로 정제된 액상 포맷, 2 mg/mL 농도. 4°C 단기 보관, -20°C 장기 보관 권장. 연구용으로만 사용 가능.
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Applications
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:200
Immunocytochemistry (ICC/IF)
- Tested Dilution: 1:200
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Mouse |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 2-E7 |
| Immunogen | Recombinant protein within mouse ATRX aa 2236–2416 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 2 mg/mL |
| Purification | Protein G |
| Storage Buffer | PBS, pH 7.4, with 40% Glycerol, 0.2% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2802533 |
Target Information
ATRX encodes a protein that contains an ATPase/helicase domain, belonging to the SWI/SNF family of chromatin remodeling proteins. Mutations in this gene are associated with X-linked mental retardation (XLMR) and alpha-thalassemia (ATRX) syndrome. These mutations affect DNA methylation patterns, linking chromatin remodeling, DNA methylation, and gene expression in development. ATRX undergoes cell cycle-dependent phosphorylation, influencing nuclear matrix and chromatin association, suggesting roles in interphase gene regulation and mitotic chromosomal segregation. Multiple alternatively spliced transcript variants encoding distinct isoforms have been reported.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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