Thermo Fisher Scientific GSK-3b Polyclonal Antibody
GSK-3β 단백질의 C-말단 합성 펩타이드를 면역원으로 제작된 Rabbit Polyclonal 항체. Western blot 및 IHC(P) 검증 완료. 인간, 마우스, 랫트 반응성. 항원 친화 크로마토그래피로 정제, PBS 완충액 내 보존.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.1–1 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 2–10 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide corresponding to the C-terminus of GSK-3β protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS with proprietary stabilizer |
| Contains | 0.01% sodium azide |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Positive control: Human breast adenocarcinoma
- Cellular location: Cytoplasm, Nucleus, Cell membrane
Target Information
GSK3B is a proline-directed serine/threonine protein kinase involved in energy metabolism, neuronal cell development, and body pattern formation.
It acts as a negative regulator of glucose homeostasis and participates in pathways related to energy metabolism, inflammation, ER-stress, mitochondrial dysfunction, and apoptosis.
GSK3B is a key component of the Wnt/β-catenin signaling pathway, mediating β-catenin degradation and inhibiting Wnt signaling.
It is also involved in Hedgehog, Notch, and insulin signaling pathways.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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