Thermo Fisher Scientific Beta-2 Microglobulin (Renal Failure and Tumor Marker) Monoclonal Antibody (rB2M/7279)
Beta-2 Microglobulin 단백질을 표적하는 Mouse Monoclonal Antibody로, 인간 및 영장류 시료에 반응. IHC(P) 및 IHC(PFA) 실험에 적합하며, 단백질 A로 정제된 액상 형태. 신장 기능 및 종양 마커 연구용으로 사용 가능.
- 카탈로그번호
- 567-MSM9-P1ABX
- 판매단위
- pk
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Applications
- Immunohistochemistry (Paraffin) (IHC (P)): Assay-dependent
- Immunohistochemistry (PFA fixed) (IHC (PFA)): 1–2 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Non-human primate |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | rB2M/7279 |
| Immunogen | Recombinant full-length human B2M protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Beta-2-microglobulin (B2M) is a 12–14 kDa protein that forms part of the major histocompatibility complex (MHC) class I. It is associated with HLA Class I antigens and expressed on various cell types including lymphocytes, thymocytes, monocytes, granulocytes, platelets, endothelial, and epithelial cells, but absent on erythrocytes. B2M is also found freely in plasma and shares structural homology with immunoglobulin constant regions, forming a beta-pleated sheet structure. It plays roles in antigen processing, presentation, and TCR signaling, particularly in CD8+ cells. The B2M gene is located on chromosome 15, and mutations can cause hypercatabolic hypoproteinemia. Beta-2-microglobulin levels are used to assess renal function and serve as a prognostic marker for HIV infection.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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