Thermo Fisher Scientific Beta-2 Microglobulin Recombinant Rabbit Monoclonal Antibody (B2M, 1857R)

Thermo Fisher Scientific Beta-2 Microglobulin Recombinant Rabbit Monoclonal Antibody (B2M, 1857R)

Applications and Tested Dilution

Product Specifications

Product Specific Information

• Immunohistochemistry (PFA fixed): Incubate antibody for 30 minutes at room temperature.
• Staining of formalin-fixed tissues requires heating tissue sections in 10 mM Tris with 1 mM EDTA, pH 9.0, for 45 minutes at 95°C, followed by cooling at room temperature for 20 minutes.

Target Information

Beta-2-microglobulin (B2M) is a 12–14 kDa protein that is a subunit of the major histocompatibility complex (MHC) class I.
Human beta-2 microglobulin associated with HLA Class I antigens is expressed on many cell types including lymphocytes, thymocytes, monocytes, granulocytes, platelets, endothelial cells, and epithelial cells, but is absent on erythrocytes.
It is also found in free form in plasma. The amino acid sequence of beta-2-microglobulin is homologous to the constant regions of immunoglobulin heavy and light chains, with a predominantly beta-pleated sheet structure.
The protein is ubiquitously expressed in the cytoplasm and is involved in antigen processing and presentation.
Beta-2-microglobulin plays a role in TCR signaling and downstream signaling in naive CD8+ cells.
Encoded by the B2M gene located on chromosome 15, mutations in this gene can result in hypercatabolic hypoproteinemia.
Levels of beta-2 microglobulin can be used to assess renal function in kidney transplant recipients and serve as a prognostic marker for HIV infection.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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