Thermo Fisher Scientific Beta-2 Microglobulin Recombinant Rabbit Monoclonal Antibody (B2M, 1857R)
Beta-2 Microglobulin 단백질을 인식하는 토끼 유래 재조합 단클론 항체로, WB, IHC, ICC, Flow 등 다양한 분석에 사용 가능. Human 및 비인간 영장류 반응성. 고순도 Protein A 정제, 200 µg/mL 농도, PBS 버퍼에 BSA 및 sodium azide 포함.
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Thermo Fisher Scientific Beta-2 Microglobulin Recombinant Rabbit Monoclonal Antibody (B2M, 1857R)
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1–2 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1–2 µg/mL |
| Immunocytochemistry (ICC/IF) | Assay-dependent |
| Flow Cytometry (Flow) | 1–2 µg/10⁶ cells |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Non-human primate |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | B2M, 1857R |
| Immunogen | Recombinant full-length human B2M protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Protein A |
| Storage Buffer | PBS, pH 7.4, with 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Immunohistochemistry (PFA fixed): Incubate antibody for 30 minutes at room temperature.
- Staining of formalin-fixed tissues requires heating tissue sections in 10 mM Tris with 1 mM EDTA, pH 9.0, for 45 minutes at 95°C, followed by cooling at room temperature for 20 minutes.
Target Information
Beta-2-microglobulin (B2M) is a 12–14 kDa protein that is a subunit of the major histocompatibility complex (MHC) class I.
Human beta-2 microglobulin associated with HLA Class I antigens is expressed on many cell types including lymphocytes, thymocytes, monocytes, granulocytes, platelets, endothelial cells, and epithelial cells, but is absent on erythrocytes.
It is also found in free form in plasma. The amino acid sequence of beta-2-microglobulin is homologous to the constant regions of immunoglobulin heavy and light chains, with a predominantly beta-pleated sheet structure.
The protein is ubiquitously expressed in the cytoplasm and is involved in antigen processing and presentation.
Beta-2-microglobulin plays a role in TCR signaling and downstream signaling in naive CD8+ cells.
Encoded by the B2M gene located on chromosome 15, mutations in this gene can result in hypercatabolic hypoproteinemia.
Levels of beta-2 microglobulin can be used to assess renal function in kidney transplant recipients and serve as a prognostic marker for HIV infection.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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