Thermo Fisher Scientific PAX2 Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Target Information

The pax genes are a family of transcription factors active in specific tissues during early embryonic development. Pax family members possess a DNA-binding domain encoded by the paired box, allowing them to regulate genetic programs. Several pax genes are associated with developmental mutations, such as:

• pax-3: associated with Waardenburg syndrome
• pax-6: associated with Aniridia
• pax-2: associated with Wilms tumor

During embryogenesis, Pax-2 is expressed in the developing kidney, particularly in condensing metanephric mesenchyme and early epithelial structures derived from mesenchyme. Pax-2 mRNA and protein levels are rapidly downregulated as the tubular epithelium matures. However, Pax-2 expression persists in the undifferentiated epithelium of Wilms’ tumors, correlating with proliferation of poorly differentiated epithelial cells. Expression of the Wilms’ tumor suppressor protein WT1 coincides with down-regulation of pax-2, suggesting WT1 can directly repress pax-2 transcription.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.