Thermo Fisher Scientific P-Selectin Monoclonal Antibody (AK-6), FITC

Applications

• Flow Cytometry (Flow): Assay-dependent

Product Specifications

Product Specific Information

• For FACS analysis, use 10 µL of the suggested working dilution to label 1×10⁶ cells in 100 µL.
• Mouse anti-human CD62P antibody, clone AK-6 recognizes CD62P (P-selectin), also known as:
  • Granule membrane protein 140 (GMP140)
  • Leukocyte-endothelial cell adhesion molecule 3 (LECAM3)
  • Platelet activation-dependent granule-external membrane protein

Target Information

P-selectin (Selectin P, GMP-140, LECAM3, CD62 antigen-like family member) is a 140 kDa type I transmembrane glycoprotein involved in cell rolling regulation. It is stored in the Weibel-Palade bodies of endothelial cells and α-granules of platelets and rapidly translocates to the cell surface upon activation by thrombin, histamine, complement 5a, Ca²⁺ ionophores, or ADP.
P-selectin mediates interactions between activated endothelial cells or platelets and leukocytes, playing a key role in leukocyte adhesion and inflammation. It binds calcium-dependently to sialylated Lewis carbohydrate antigens on neutrophils and monocytes and is implicated in atherogenesis, thrombosis, and tissue injury. Clinically, P-selectin helps distinguish heparin-induced thrombocytopenia with or without thrombosis.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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