Thermo Fisher Scientific SGK196 Monoclonal Antibody (OTI2B10), TrueMAB
인간 SGK196 단백질을 표적으로 하는 마우스 단클론 항체로, Western blot 및 IHC에 적합합니다. 고순도 친화 크로마토그래피 정제, 동결건조 형태로 제공되며, 트레할로스 포함 PBS buffer에 재구성 가능합니다. 연구용으로만 사용됩니다.
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Thermo Fisher Scientific SGK196 Monoclonal Antibody (OTI2B10), TrueMAB
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:150 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI2B10 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 141–350 of human SGK196 produced in E. coli |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments using this carrier-free antibody, perform desalting using Zeba Spin Desalting Columns (7K MWCO, 0.5 mL, Product #89882).
Target Information
The SGK196 gene encodes a protein involved in the presentation of the laminin-binding O-linked carbohydrate chain of alpha-dystroglycan (a-DG), which forms transmembrane linkages between the extracellular matrix and the exoskeleton.
Some pathogens utilize this O-linked carbohydrate unit for host entry.
Loss-of-function compound heterozygous mutations in this gene have been associated with Walker-Warburg syndrome (WWS).
Mice lacking this gene exhibit misplaced neurons (heterotopia) in certain brain regions, possibly due to defects in neuronal migration.
Alternative splicing results in multiple transcript variants.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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