Thermo Fisher Scientific SGK196 Monoclonal Antibody (OTI1B1), TrueMAB
SGK196 단백질을 인식하는 Mouse IgG2a 단일클론 항체로, Western blot과 IHC(P)에서 검증됨. Human 시료에 반응하며, PBS 완충액(8% 트레할로스) 내 동결건조 형태로 제공. 연구용으로만 사용 가능.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:150 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2a |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI1B1 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 141–350 of human SGK196 produced in E. coli |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage Conditions | −20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL distilled water to obtain a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments using this carrier-free antibody, perform an additional desalting step (e.g., Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).
Target Information
The SGK196 gene encodes a protein potentially involved in the presentation of the laminin-binding O-linked carbohydrate chain of alpha-dystroglycan (α-DG), which mediates transmembrane linkages between the extracellular matrix and the cytoskeleton.
Certain pathogens exploit this O-linked carbohydrate unit for host entry.
Loss-of-function compound heterozygous mutations in this gene have been associated with the Walker-Warburg syndrome (WWS) phenotype.
Mice lacking this gene exhibit misplaced neurons (heterotopia) in some brain regions, possibly due to defects in neuronal migration.
Alternative splicing results in multiple transcript variants.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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