Thermo Fisher Scientific Phospho-PAK1/PAK2 (Ser144, Ser141) Polyclonal Antibody
Human, Mouse, Rat에서 인식되는 phospho-PAK1/PAK2 (Ser144, Ser141) rabbit polyclonal antibody. Western blot에 최적화됨. 항원 친화 크로마토그래피로 정제. -20°C 보관, 방부제 없음. 연구용 전용.
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Applications
Western Blot (WB)
- Tested Dilution: 1:1,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic phosphopeptide corresponding to residues surrounding pSer144 of human PAK1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 139 µg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | 0.01M HEPES (pH 7.5), 0.15M NaCl, 100 µg/mL BSA, 50% glycerol |
| Contains | No preservative |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_10986434 |
Product Specific Information
- It is not recommended to aliquot this antibody.
- This antibody is not cross-reactive with phosphorylated PAK4-6.
Target Information
Three isoforms of serine/threonine kinases, designated alphaPAK p68, betaPAK p65, and gammaPAK p62, exhibit a high degree of sequence homology with the S. cerevisiae kinase Ste20, involved in pheromone signaling.
The alpha, beta, and gammaPAK isoforms complex specifically with Rac1 and Cdc42 in their active GTP-bound state, inhibiting their intrinsic GTPase activity and leading to their autophosphorylation.
There are eight sites of autophosphorylation on gammaPAK, including Ser19, Ser141, and Thr402, and phosphorylation of Ser141 and Thr402 is correlated with gammaPAK activation.
Once phosphorylated and their affinity for Rac/Cdc42 reduced, the PAK isoforms dissociate from the complex to seek downstream substrates.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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