Thermo Fisher Scientific Phospho-CHK1 (Ser317) Polyclonal Antibody
Phospho-CHK1 (Ser317) 폴리클로날 항체로 DNA 손상 반응 연구에 적합. Western blot 및 ICC/IF에 사용 가능. Rabbit IgG 기반으로 항원 친화 크로마토그래피로 정제됨. 인산화된 CHK1 단백질 검출용 연구 시약.
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Applications
Western Blot (WB)
- Tested Dilution: 1:1,000
Immunocytochemistry (ICC/IF)
- Tested Dilution: 1:100
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mink, Non-human primate, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic phosphopeptide corresponding to residues surrounding pSer317 of human Chk1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification | Antigen affinity chromatography |
| Storage buffer | 0.01M HEPES, pH 7.5, with 0.15M NaCl, 100µg/mL BSA, 50% glycerol |
| Contains | No preservative |
| Storage conditions | -20°C |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_10977443 |
Product Specific Information
It is not recommended to aliquot this antibody.
Target Information
CHEK1 (CHK1) is a serine/threonine protein kinase involved in preventing replication when DNA integrity is compromised. CHK1 is a key mediator in the DNA damage-induced checkpoint network. It functions to ensure genomic integrity upon genotoxic stress. Inhibition of CHK1 can lead to mitotic catastrophe in p53-deficient cancer cells, while normal cells remain arrested in the G1 phase. Therefore, CHK1 is an attractive therapeutic target for cancer treatment, particularly in p53-deficient cancers.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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