Thermo Fisher Scientific FGFR3 Recombinant Rabbit Monoclonal Antibody (JM81-10)
FGFR3 단백질을 표적으로 하는 Thermo Fisher Scientific의 재조합 토끼 모노클로날 항체입니다. Western blot, IHC, ICC/IF, Flow cytometry에 사용 가능하며 높은 특이성과 민감도를 제공합니다. HEK293 발현 시스템 기반, Protein A 정제, 1 mg/mL 농도.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:5,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
| Flow Cytometry (Flow) | 1:50–1:100 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | JM81-10 |
| Immunogen | Recombinant protein within Human FGFR3 aa 719–806 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | TBS, pH 7.4, with 40% Glycerol, 0.05% BSA |
| Contains | 0.05% Sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2809872 |
Product Specific Information
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. Antibody DNA sequences from immunoreactive rabbits are cloned and screened to select the best candidates for production.
Advantages include:
- Better specificity and sensitivity
- Lot-to-lot consistency
- Animal origin-free formulations
- Broader immunoreactivity to diverse targets due to larger rabbit immune repertoire
Target Information
FGFR3 belongs to the FGFR family of receptor tyrosine kinases, which regulate various cellular functions such as angiogenesis, mitogenesis, osteogenesis, myogenesis, carcinogenesis, differentiation, and tissue repair.
FGFR family members differ in ligand affinities and tissue distribution. FGFR3 interacts with fibroblast growth factors, initiating signaling cascades influencing mitogenesis and differentiation.
It plays a role in bone development and maintenance. Mutations in FGFR3 are associated with craniosynostosis and skeletal dysplasia. Three alternatively spliced transcript variants encoding different isoforms have been described.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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