Thermo Fisher Scientific TLR5 Recombinant Rabbit Monoclonal Antibody (JM10-88)

Applications

Western Blot (WB)

• Tested Dilution: 1:1,000–1:2,000

Immunohistochemistry (Paraffin) (IHC (P))

• Tested Dilution: 1:50–1:200

Product Specifications

Product Specific Information

Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems developed by cloning specific antibody DNA sequences from immunoreactive rabbits. Individual clones are screened to select optimal candidates for production.
Advantages include:

• High specificity and sensitivity
• Lot-to-lot consistency
• Animal origin-free formulations
• Broader immunoreactivity due to larger rabbit immune repertoire

Target Information

TLR5 is a type I membrane protein belonging to the Toll-like receptor family and plays a key role in innate immune responses to microbial agents. It mediates detection of bacterial flagellins and acts via MyD88 and TRAF6, leading to NF-κB activation, cytokine secretion, and inflammation.
TLR5 is highly expressed in liver, detected in lung, and at low levels in other tissues. The gene locus is associated with susceptibility to Salmonella. Mouse strains vary in resistance to S. typhimurium infection. A common TLR5 stop codon polymorphism disrupting TLR5 signaling is linked to susceptibility to Legionnaires’ disease, highlighting its importance in innate immunity.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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