Thermo Fisher Scientific FOXL2 Polyclonal Antibody
FOXL2 단백질을 인식하는 Rabbit Polyclonal Antibody로, Western blot, IHC, ICC/IF, ChIP 등 다양한 응용에 적합. 마우스, 햄스터, 인간 시료에서 반응하며 고순도 항원 친화 정제 방식으로 제조. 연구용으로만 사용 가능.
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Applications and Tested Dilutions
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 0.2 µg/mL | View 1 publication |
| Immunohistochemistry (IHC) | - | View 1 publication |
| Immunohistochemistry (Paraffin) (IHC (P)) | 0.2 µg/mL | View 1 publication |
| Immunocytochemistry (ICC/IF) | 2 µg/mL | - |
| ChIP assay (ChIP) | 1–3 µg × 10⁶ cells | - |
| Miscellaneous PubMed (Misc) | - | View 1 publication |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Hamster, Human, Mouse |
| Published Species | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to residues M(1)MASYPEPEDTAGT(14) of mouse FoxL2 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS with 1 mg/mL BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2278574 |
Product Specific Information
PA1-802 detects FoxL2 protein in mouse and hamster samples.
It has been validated for use in Western blot, immunofluorescence, and immunohistochemistry.
By Western blot, this antibody detects an approximately 39 kDa protein representing FoxL2 in CHO whole cell lysate.
The immunogen is a synthetic peptide corresponding to residues M(1)MASYPEPEDTAGT(14) of mouse FoxL2.
This sequence is completely conserved in mouse and rat and 92% conserved in human.
The corresponding peptide (Cat. # PEP-238) is available for use in neutralization and control experiments.
Target Information
FOXL2 is a winged helix/forkhead transcription factor highly conserved across species such as human, goat, mouse, and aquatic organisms.
It plays an essential role in ovarian differentiation and follicle development.
FOXL2 is a nuclear protein expressed in eyelids and ovarian follicular cells in both fetal and adult tissues.
It is associated with blepharophimosis/ptosis/epicanthus inverses syndrome (BPES), which exists in two forms:
- Type I BPES: Eyelid abnormalities with ovarian failure
- Type II BPES: Eyelid defects only
Studies show FOXL2 expression in developing mouse eyelid mesenchyme and adult ovarian follicles.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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