Thermo Fisher Scientific ASIC1 Monoclonal Antibody (N271/44), PerCP

Applications and Tested Dilution

Product Specifications

Additional Formats Available

• Unconjugated
• APC
• FITC
• PE
• Request custom conjugation

Product Specific Information

• 1 µg/mL of MA5-45594 was sufficient for detection of ASIC1 in 20 µg of rat brain lysate by colorimetric immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody.
• Detects approximately 60 kDa.
• This antibody was formerly sold as clone S271-44.

Target Information

This gene encodes a member of the degenerin/epithelial sodium channel (DEG/ENaC) superfamily. Members of this family are amiloride-sensitive sodium channels with intracellular N and C termini, two hydrophobic transmembrane regions, and a large extracellular loop containing many cysteine residues with conserved spacing.

The encoded protein is expressed in most brain neurons and may function as an ion channel subunit. ASIC1 is a cation channel with high affinity for sodium, gated by extracellular protons, and inhibited by amiloride. It is permeable to Ca²⁺, Li⁺, and K⁺ ions and is expressed in dorsal root ganglia, sciatic nerves, olfactory bulb, cortical regions, hippocampal formation, amygdala, cerebellum, and other brain regions. Isoform 3 is expressed only in dorsal root ganglion, while isoform 1 is expressed in DRG, spinal cord, trigeminal ganglia, and the trigeminal mesencephalic nucleus.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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