Thermo Fisher Scientific Phospho-PFKFB2 (Ser483) Polyclonal Antibody
PFKFB2 단백질의 Ser483 인산화 부위를 인식하는 폴리클로날 항체로, WB 및 IHC(P) 분석에 적합합니다. 인간, 마우스, 랫트 반응성을 가지며, 항원 친화 크로마토그래피로 정제되었습니다. 고순도(>95%)이며, 58 kDa 내인성 단백질 검출이 가능합니다.
- 판매단위
- pk
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Thermo Fisher Scientific Phospho-PFKFB2 (Ser483) Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic phosphopeptide derived from human PFKFB2 around the phosphorylation site of Serine 483 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2553793 |
Product Specific Information
- Detects endogenous PFKFB2 protein at a molecular weight of 58 kDa.
- Purity >95% by SDS-PAGE.
Target Information
Protein kinases are enzymes that transfer phosphate groups from donors (typically ATP) to acceptor amino acids in substrate proteins. Through this mechanism, they mediate most signal transduction in eukaryotic cells, regulating metabolism, transcription, cell cycle progression, cytoskeletal organization, apoptosis, and differentiation.
The protein kinase family includes over 500 gene products, classified into 8 major groups based on catalytic domain sequences. The AGC kinase group comprises 63 kinases, including:
- PKA & PKG (cyclic nucleotide-regulated kinases)
- PKC (phospholipid-dependent kinases)
- RAC/Akt kinases (related to PKA and PKC)
- ARK (kinases phosphorylating GPCRs)
- RSK (kinases phosphorylating ribosomal protein S6)
Usage Note
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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