Thermo Fisher Scientific CD261 (DR4) Monoclonal Antibody (DJR1), eBioscience
인간 DR4(TRAIL-R1) 인식하는 DJR1 단클론 항체로, Flow Cytometry와 IHC(Frozen) 등에 사용 가능. TRAIL 매개 세포사멸 연구에 적합하며, 고순도(>90%) 및 낮은 응집(<10%) 특성. 4°C 보관, PBS 버퍼 및 sodium azide 포함.
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Thermo Fisher Scientific CD261 (DR4) Monoclonal Antibody (DJR1), eBioscience
Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | - | View 1 publication |
| Immunohistochemistry (Frozen) (IHC (F)) | Assay-Dependent | View 1 publication |
| Immunocytochemistry (ICC/IF) | - | View 1 publication |
| Flow Cytometry (Flow) | 1 µg/test | View 6 publications |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Published Species | Human |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | DJR1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.2 |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2865223 |
Available Formats:
Product Specific Information
Description:
The DJR1 monoclonal antibody reacts with human DR4 (TRAIL-R1). DR4 binds to TRAIL, activates NF-kappaB, and induces TRAIL-mediated apoptosis. DR4 is expressed by various human tumor cells and at low levels on human leukocytes. Expression has also been found intracellularly in some cell lines (Zhang et al.), confirmed via intracellular staining of Jurkat cells.
Applications Reported:
- Flow cytometric analysis
- Immunohistology staining of frozen tissue sections
Applications Tested:
Tested by flow cytometric analysis of human DR4-transfected cells, usable at ≤1 µg per test (100 µL final volume). Optimal performance requires titration based on cell number (10⁵–10⁸ cells/test).
Purity: >90% (SDS-PAGE)
Aggregation: <10% (HPLC)
Filtration: 0.2 µm post-manufacturing filtered
Target Information
TRAIL-R1 (CD261, DR4) is a type I transmembrane protein, also known as TRAIL receptor 1. Its ligand, TRAIL, belongs to the TNF family. DR4 mediates apoptosis and NF-kappaB activation, similar to Fas and TNFR1 receptors. Apoptosis, a programmed cell death process, is essential for normal cellular differentiation and development. It is induced through cytokines such as TNF and Fas ligand interacting with death domain-containing receptors (TNFR1, Fas receptor).
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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