Thermo Fisher Scientific CD8a Monoclonal Antibody (SK1), PerCP-eFluor 710, eBioscience
CD8a 단백질을 표적하는 SK1 단클론 항체로, PerCP-eFluor 710 형광체가 결합된 제품입니다. 인간 및 원숭이 시료에 반응하며, 유세포 분석(Flow Cytometry)에 최적화되어 있습니다. T 세포 및 NK 세포 표지에 활용 가능하며, 4°C 암소 보관을 권장합니다.
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Thermo Fisher Scientific CD8a Monoclonal Antibody (SK1), PerCP-eFluor 710, eBioscience
Applications
- Flow Cytometry (Flow)
Tested Dilution: 5 µL (0.125 µg)/test
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Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Published Species | Human, Rhesus monkey |
| Host / Isotype | Mouse / IgG1, kappa |
| Recommended Isotype Control | Mouse IgG1 kappa Isotype Control (P3.6.2.8.1), PerCP-eFluor™ 710 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | SK1 |
| Conjugate | PerCP-eFluor™ 710 |
| Excitation / Emission Max | 482 / 708 nm |
| Form | Liquid |
| Concentration | 5 µL/Test |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 0.2% BSA |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C, store in dark, DO NOT FREEZE |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_1834412 |
Additional Formats Available
- Alexa Fluor 700
- APC
- APC-eFluor 780
- Brilliant UV 805
- Brilliant Violet 650
- eFluor 450
- FITC
- NovaFluor Blue 610-70S
- NovaFluor Blue 660-120S
- NovaFluor Blue 690
- NovaFluor Yellow 730
- NovaFluor Yellow 755
- PE
- PE-Cyanine7
- PE-eFluor 610
- Super Bright 436
- Super Bright 600
- Super Bright 702
- Request custom conjugation
Product Specific Information
The SK1 monoclonal antibody reacts with human CD8a, a 32–34 kDa cell surface receptor expressed as CD8 alpha/beta heterodimers or CD8 alpha/alpha homodimers. CD8a is present on thymocytes, mature T cells, and NK cells, and binds to MHC class I molecules. Through association with p56lck kinase, CD8a contributes to T-cell development and activation.
- Applications Reported: Flow cytometric analysis
- Applications Tested: Pre-titrated and tested on normal human peripheral blood cells at 5 µL (0.125 µg)/test
- Recommended Filters: 710/50 bandpass (preferred), 695/40 bandpass (alternative)
- Laser: Blue Laser (488 nm excitation, 710 nm emission)
- Fixation: Samples can be stored in IC Fixation Buffer (Product #00-8222-49) or 1-step Fix/Lyse Solution (Product #00-5333-54) for up to 3 days at 4°C in the dark
- Filtration: 0.2 µm post-manufacturing filtered
Target Information
Cluster of differentiation 8 (CD8) is a type I transmembrane glycoprotein involved in T-cell signal transduction, differentiation, and activation. CD8 forms disulfide-linked heterodimers (CD8α/β) or homodimers (CD8α/α) and acts as a co-receptor for MHC class I molecules. It is expressed on T cells, NK cells, monocytes, and dendritic cells. Binding of MHC-I/peptide complexes triggers Lck kinase activation, leading to cytokine production and cytotoxic T lymphocyte (CTL) activation. CTLs play a key role in pathogen and tumor cell clearance, with differentiation enhanced by IL-2, IL-12, and TGF-β1.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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