Thermo Fisher Scientific INSR beta Recombinant Superclonal Antibody (6HCLC)

Applications and Tested Dilution

Product Specifications

Product Specific Information

This antibody is predicted to react with mouse based on sequence homology.

Recombinant rabbit Superclonal™ antibodies are unique offerings from Thermo Fisher Scientific. They consist of multiple different recombinant monoclonal antibodies, combining the sensitivity of polyclonal antibodies with the specificity of monoclonal antibodies, while maintaining batch-to-batch consistency.

Functionally similar to polyclonal antibodies, they recognize multiple epitopes on the target, providing higher detection sensitivity for low-abundance proteins. Each lot contains a defined mixture of light and heavy chains, eliminating biological variability common in polyclonal production.

Note: Formerly called “Recombinant Polyclonal Antibody”, now rebranded as “Recombinant Superclonal™ Antibody”. The product and performance remain unchanged.

Target Information

The biological actions of insulin and IGF-1 are mediated by their respective receptor tyrosine kinases, which regulate multiple signaling pathways through phosphorylation cascades. Binding of insulin or IGF-1 to the extracellular domain induces autophosphorylation and activation of downstream targets.

Differences in receptor sequence confer ligand specificity and distinct intracellular signaling outcomes. Defects in the insulin receptor (IR) are linked to insulin resistance syndromes, while IGF-1R defects can cause growth retardation. Both pathways are also implicated in cancer development.

For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.