Thermo Fisher Scientific JNK1 Recombinant Polyclonal Antibody (2HCLC)

Applications

Tested Dilution

Publications

Western Blot (WB)

0.5-3 µg/mL

-

Immunohistochemistry (Paraffin) (IHC (P))

1:10-1:100

-

Product Specifications

Host/Isotype

Rabbit / IgG

Class

Recombinant Superclonal

Type

Antibody

Clone

2HCLC

Immunogen

Recombinant protein corresponding to amino acids 17-126 of human JNK1 if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:JNK1,uniProtId:P45983-1,ncbiNodeId:9606,antigenRange:17-126,antigenLength:427,antigenImageFileName:710075_JNK1_P45983-1_Rabbit.svg,antigenImageFileNamePDP:710075_JNK1_P45983-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.5 mg/mL

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice (domestic); Wet or Dry ice (international)

RRID

AB_2532544

Product Specific Information

This antibody is predicted to react with mouse based on sequence homology.

Recombinant rabbit polyclonal antibodies are unique offerings from Thermo Fisher Scientific. They are comprised of a selection of multiple different recombinant monoclonal antibodies, providing the best of both worlds - the sensitivity of polyclonal antibodies with the specificity of monoclonal antibodies - all delivered with the consistency only found in a recombinant antibody. While functionally the same as a polyclonal antibody - recognizing multiple epitope sites on the target and producing higher detection sensitivity for low abundance targets - a recombinant rabbit polyclonal antibody has a known mixture of light and heavy chains. The exact population can be produced in every lot, circumventing the biological variability typically associated with polyclonal antibody production.

Target Information

MAPK8 (JNK1) is activated by the presence of misfolded proteins in the endoplasmic reticulum. It is also a crucial mediator of insulin resistance and obesity. It belongs to the MAPK superfamily of stress-activated protein kinases. MAPKs are Serine-threonine protein kinases that are activated in response to a variety of extracellular stimuli, and mediate signal transduction from the cell surface to the nucleus. JNK is involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. JNK pathways are activated by stress and inflammatory signals. JNK is expressed as ten different isoforms due to differential mRNA splicing. The predominant forms are JNK1 and JNK2.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.