Thermo Fisher Scientific IDO1 Monoclonal Antibody (2E2.6)
IDO1 단백질에 특이적인 마우스 단클론 항체로 Western blot, IHC, Flow cytometry 등 다양한 응용에 사용 가능. 비결합형 액상 형태이며 Protein A로 정제됨. -20°C에서 보관, 인간 조직과 반응하지 않음.
- 카탈로그번호
- 210-301-E58x (2개 옵션)
- 판매단위
- pk
카탈로그
2개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific IDO1 Monoclonal Antibody (2E2.6)
Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,500 |
| Immunohistochemistry (IHC) | Assay-dependent |
| Flow Cytometry (Flow) | 0.5 µL / 1×10⁶ cells |
| ELISA | 1:5,000–1:50,000 |
| Immunoprecipitation (IP) | 10–100 µL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Mouse |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 2E2.6 |
| Immunogen | IDO1 antibody was produced in mouse by repeated immunizations with mouse recombinant IDO1 protein followed by hybridoma development. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | 0.02M potassium phosphate (pH 7.2), 0.15M NaCl |
| Contains | 0.01% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Store vial at -20°C prior to opening.
- Aliquot and freeze at -20°C or below for long-term storage.
- Avoid repeated freeze/thaw cycles.
- Centrifuge if not clear after standing at room temperature.
- Stable for several weeks at 4°C as undiluted liquid.
- Dilute only before immediate use.
IDO1 antibody is specific for mouse IDO1 protein and does not react with human tissues.
Cross-reactivity with IDO1 from other species has not been determined.
Target Information
Indoleamine 2,3-dioxygenase 1 (IDO1) is an intracellular heme-containing enzyme that catalyzes the oxidative cleavage of the indole ring of regulatory molecules such as tryptophan, serotonin, and melatonin. This reaction initiates the production of biologically active metabolites known as kynurenines.
IDO1 is expressed in various human tissues, macrophages, and dendritic cells. During inflammation, interferons (IFNs) induce IDO1 expression, contributing to antimicrobial defense by depleting tryptophan and inhibiting pathogen growth.
IDO1 also plays a key role in immune regulation during infection, pregnancy, autoimmunity, transplantation, and cancer.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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