Thermo Fisher Scientific EBI3 Monoclonal Antibody (V1.4H6.29), Biotin

Applications and Tested Dilution

Product Specifications

Additional Formats

• Unconjugated
• Request custom conjugation

Product Specific Information

Store vial at 4°C prior to restoration. Restore with 0.1 mL of deionized water (or equivalent). For extended storage, aliquot contents and freeze at -20°C or below. Avoid freeze/thaw cycles. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4°C as an undiluted liquid. Dilute only prior to immediate use.

This antibody is specific for mouse EBI3 protein. A BLAST analysis indicates 100% homology with the immunizing sequence from mouse EBI3. Cross-reactivity with EBI3 from other species has not been determined.

Target Information

EBI3 (Epstein-Barr virus Induced-3) is a secreted glycoprotein of the hematopoietin receptor family. It plays a key regulatory role in Th2-type immune responses and tissue inflammation by modulating iNKT cell function. EBI3 forms heterodimers with IL-12 subunits (p28 and p35) to generate IL-27 and IL-35, which regulate Th17 differentiation and immune homeostasis. Its expression in dendritic cells is controlled by TLR signaling via MyD88 and NF-κB pathways. EBI3 also influences tumor metastasis through CD8+ T cell regulation and is associated with Th2 cytokine production in allergic inflammation.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.