Thermo Fisher Scientific LPIN1 Recombinant Rabbit Monoclonal Antibody (JG37-69)
LPIN1 단백질을 표적으로 하는 재조합 토끼 단클론 항체로, Western blot, IHC, ICC, 유세포분석에 적합합니다. 인간 시료에 반응하며, 고순도의 Protein A 정제 항체입니다. 지방 대사 및 인슐린 감수성 연구에 활용 가능합니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
| Flow Cytometry (Flow) | 1:50–1:100 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | JG37-69 |
| Immunogen | Recombinant protein within Human Lipin 1 (aa 81–220) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.0 mg/mL |
| Purification | Protein A |
| Storage Buffer | TBS, pH 7.4, with 40% glycerol, 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | -20°C, avoid freeze/thaw cycles, store in dark |
| Shipping Conditions | Wet ice |
| RRID | AB_2848673 |
Product Specific Information
Positive Control: K562, SH-SY-5Y, HUVEC, PC-3M, human liver cancer tissue, human colon tissue, human skeletal muscle tissue.
Target Information
The Lipin family of nuclear proteins includes Lipin-1, Lipin-2, and Lipin-3, each containing a nuclear signal sequence, a conserved NLIP domain, and a CLIP domain. LPIN1 (Lipin-1) is essential for normal adipose tissue development and metabolism. It activates PGC-1A target pathways involved in fatty acid oxidation and mitochondrial oxidative phosphorylation by inducing PPARA expression. LPIN1 also suppresses lipogenesis and circulating lipid levels. Overexpression promotes fat accumulation and insulin sensitivity, while deficiency can cause lipodystrophy and insulin resistance.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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