Thermo Fisher Scientific CD278 (ICOS) Monoclonal Antibody (ISA-3), Alexa Fluor 700, eBioscience
휴먼 ICOS(CD278) 인식 단클론 항체로, Alexa Fluor 700으로 표지되어 Flow Cytometry에 최적화됨. T세포 활성화 및 면역반응 연구용. ISA-3 클론 기반, 고순도 친화 크로마토그래피 정제. 연구용 전용 제품.
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Thermo Fisher Scientific CD278 (ICOS) Monoclonal Antibody (ISA-3), Alexa Fluor 700, eBioscience
Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Flow Cytometry (Flow) | 5 µL (0.5 µg)/test | View 11 publications |
| Neutralization (Neu) | - | View 1 publication |
| Functional Assay (Functional) | - | View 2 publications |
Product Specifications
| Property | Description |
|---|---|
| Species Reactivity | Human |
| Published Species | Not Applicable |
| Host / Isotype | Mouse / IgG1, kappa |
| Recommended Isotype Control | Mouse IgG1 kappa Isotype Control (P3.6.2.8.1), Alexa Fluor™ 700, eBioscience™ |
| Class | Monoclonal |
| Type | Antibody |
| Clone | ISA-3 |
| Conjugate | Alexa Fluor™ 700 |
| Excitation / Emission Max | 696 / 719 nm |
| Form | Liquid |
| Concentration | 5 µL/test |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 0.2% BSA |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C, store in dark, DO NOT FREEZE |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2848478 |
Available Formats
- Unconjugated
- APC
- APC-eFluor 780
- Biotin
- Brilliant UV 661
- eFluor 450
- FITC
- Functional Grade
- NovaFluor Red 660
- NovaFluor Red 710
- NovaFluor Yellow 700
- NovaFluor Yellow 730
- PE
- PE-Cyanine5.5
- PE-Cyanine7
- PE-eFluor 610
- PerCP-eFluor 710
- Super Bright 436
- Super Bright 600
- Super Bright 645
- Super Bright 780
- Request custom conjugation
Product Specific Information
The ISA-3 monoclonal antibody reacts with human ICOS (Inducible COStimulatory molecule), also known as H4, CRP-1, and AILIM. ICOS is a T-cell specific activation molecule and a member of the CD28/CTLA-4 family. It plays a key role in T-cell activation and humoral immune responses, including memory B cell and plasma cell generation.
ICOS interacts with its ligand B7h/B7RP-1 expressed on activated antigen-presenting cells and inflamed peripheral tissues. Plate-bound ISA-3 induces production of cytokines such as IL-4, IL-5, and IL-10, but not IL-2. ISA-3 was generated against human ICOS antigen and shares reactivity characteristics with F44.
Applications Reported: Suitable for flow cytometric analysis.
Applications Tested: Pre-diluted and tested by flow cytometric analysis of stimulated normal human peripheral blood cells at 5 µL (0.5 µg) per test.
Alexa Fluor 700 emits at 723 nm and can be excited with a red laser (633–647 nm). Recommended optical setup: 685 LP mirror and 710/20 band pass filter.
Excitation: 633–647 nm
Emission: 723 nm
Laser: Red Laser
Target Information
ICOS (CD278) encodes a protein of the CD28/CTLA-4 receptor family. It functions as a homodimer and is crucial in cell-cell signaling, immune responses, and regulation of cell proliferation. Mutations or dysregulation are linked to immunodeficiency disorders such as Common Variable Immunodeficiency.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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