Thermo Fisher Scientific TrkA Recombinant Mouse Monoclonal Antibody (MNAC13)
TrkA 단백질의 세포외 도메인을 인식하는 Mouse IgG1 단일클론 항체. IHC, ELISA, SPR 등 다양한 분석에 사용 가능. TrkB 및 TrkC와 교차 반응 없음. Protein A로 정제된 액상 항체로, 1 mg/mL 농도. 연구용으로만 사용 가능.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (IHC) | Assay-dependent |
| ELISA | Assay-dependent |
| Inhibition Assays (IA) | Assay-dependent |
| Surface Plasmon Resonance (SPR) | Assay-dependent |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1, kappa |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | MNAC13 |
| Immunogen | Human TrkA ECD |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | Store at 4°C (short term). For long term, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_3074407 |
Product Specific Information
This antibody binds to the extracellular domain of TrkA and does not cross-react with TrkB. MNAC13 is specific to TrkA with negligible reactivity to TrkB and TrkC.
Target Information
NTRK1 (TRKA) belongs to the neurotrophic factor family of polypeptides essential for the development and maintenance of the mammalian nervous system. TrkA is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. Its presence promotes cell differentiation and may influence sensory neuron subtype specification. Mutations in TrkA have been linked to congenital insensitivity to pain, anhidrosis, self-mutilating behavior, mental retardation, and cancer.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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