Thermo Fisher Scientific TrkA Chimeric Recombinant Rabbit Monoclonal Antibody (MNAC13)
TrkA 단백질의 세포외 도메인에 특이적으로 결합하는 재조합 토끼 단클론 항체입니다. IHC, ICC/IF, ELISA 등 다양한 분석에 사용 가능하며 TrkB 및 TrkC와 교차반응이 없습니다. 고순도 Protein A 정제, 장기보관 시 -20°C에서 안정적입니다.
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Thermo Fisher Scientific TrkA Chimeric Recombinant Rabbit Monoclonal Antibody (MNAC13)
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (IHC) | Assay-dependent |
| Immunocytochemistry (ICC/IF) | 10 µg/mL |
| ELISA | Assay-dependent |
| Inhibition Assays (IA) | Assay-dependent |
| Surface Plasmon Resonance (SPR) | Assay-dependent |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG, kappa |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | MNAC13 |
| Immunogen | Human TrkA ECD |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_3074408 |
Product Specific Information
This antibody binds specifically to the extracellular domain of TrkA and does not cross-react with TrkB or TrkC. MNAC13 shows high specificity for TrkA with negligible reactivity to other related receptors.
Target Information
NTRK1 (TrkA) is a member of the neurotrophic factor receptor family, essential for the development and maintenance of the mammalian nervous system. TrkA is a membrane-bound receptor that, upon neurotrophin binding, undergoes autophosphorylation and activates the MAPK pathway. Its expression promotes cell differentiation and plays a role in sensory neuron subtype specification. Mutations in TrkA are associated with congenital insensitivity to pain, anhidrosis, self-mutilating behavior, mental retardation, and cancer.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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