Thermo Fisher Scientific Ruplizumab Recombinant Human Monoclonal Antibody (hu5c8 (Ruplizumab))
Ruplizumab은 인간 CD40L에 결합하는 재조합 인간 단일클론 항체로, 면역억제 연구에 사용됩니다. HEK293 세포에서 발현되었으며, WB 및 Flow Cytometry 등 다양한 분석에 적합합니다. 고순도 Protein A 정제, 1 mg/mL 농도의 액상 형태로 제공됩니다.
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Thermo Fisher Scientific Ruplizumab Recombinant Human Monoclonal Antibody (hu5c8, Ruplizumab)
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1 µg/mL |
| Flow Cytometry (Flow) | Assay-dependent |
| Inhibition Assays (IA) | Assay-dependent |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Human / IgG1, kappa |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | hu5c8 (Ruplizumab) |
| Immunogen | Human CD40L |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_3074409 |
Product Specific Information
- Specificity: The antibody binds to CD40L with an IC50 of 0.845 µg/mL.
Target Information
Ruplizumab is a humanized monoclonal antibody used as an immunosuppressive pharmaceutical and is a component of Antova.
It is an anti-CD40L monoclonal antibody. The binding of CD40 to its ligand, CD40L, is a critical element in T cell activation.
In systemic lupus erythematosus, CD40L is over-expressed on T cells, B cells, and monocytes.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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