Thermo Fisher Scientific Phospho-PDCD4 (Ser457) Polyclonal Antibody
PDCD4 단백질의 Ser457 인산화 형태를 특이적으로 인식하는 rabbit polyclonal antibody입니다. Western blot, IHC, ICC/IF에 사용 가능하며, 인간, 마우스, 랫트 시료에 반응합니다. 액상 형태로 제공되며 -20°C에서 보관합니다.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (IHC) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human PDCD4 (Accession Q53EL6), corresponding to amino acid residues around phosphorylated Ser457 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2816489 |
Product Specific Information
Antibody detects endogenous levels of PDCD4 only when phosphorylated at Serine 457.
Target Information
Apoptosis, also known as programmed cell death, plays major roles in development and normal tissue turnover as well as tumor formation. During this process, expression patterns of numerous genes are altered. One such gene, PDCD4, encodes a tumor suppressor protein whose expression is lost in carcinomas of breast, colon, lung, and prostate. PDCD4 can bind to and inhibit the helicase activity of eukaryotic translation initiation factor 4A and inhibit transactivation mediated by transcription factor AP-1. The kinase Akt regulates PDCD4 by phosphorylation, decreasing its ability to interfere with AP-1-responsive promoter activation by c-Jun. There are two known isoforms of PDCD4.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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