Thermo Fisher Scientific Phospho-Profilin 1 (Ser138) Polyclonal Antibody
Phospho-Profilin 1 (Ser138) 인산화 형태를 특이적으로 인식하는 Thermo Fisher Scientific의 rabbit polyclonal antibody. Western blot에 적합하며, 인간, 마우스, 랫트 시료에서 반응. 항원 친화 정제, 고순도, 안정적 액상 형태로 -20°C 보관.
- 카탈로그번호
- PA5143752
- 판매단위
- pk
카탈로그
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Applications
- Western Blot (WB)
Tested Dilution: 1:1,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Phospho-Profilin (Ser138) synthetic peptide (coupled to carrier protein) including amino acids surrounding Ser138 in human Profilin-1. Conserved in rat and mouse Profilin-1. Serine site has some homology to conserved site (Ser138) in Profilin-2a and Profilin-2b, but not conserved in Profilin-3 and Profilin-4. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | ~0.5 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS with 1 mg/mL BSA, 50% glycerol |
| Contains | 0.05% sodium azide |
| Storage conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping conditions | Wet ice |
| RRID | AB_2942980 |
Product Specific Information
This antibody was cross-adsorbed to unphosphorylated Profilin (Ser-138) and affinity purified using Profilin (Ser-138) peptide (without carrier).
Detects a 15 kDa band corresponding to Profilin-1 in human Jurkat and A431 cells, and rat PC12 cells.
Reactivity is decreased by lambda phosphatase treatment and blocked by phospho-profilin (Ser-138) blocking peptide.
Target Information
Profilin is a ubiquitous small (12–15 kDa) phosphoinositides and poly-L-proline binding protein involved in signal transduction and actin filament dynamics.
Two mammalian profilins exist with similar biochemical properties but distinct expression patterns:
- Profilin I: Highly expressed in most tissues except skeletal muscle.
- Profilin II: Predominantly expressed in brain, lower levels in skeletal muscle, uterus, and kidney.
Profilin is mainly cytosolic and concentrated at dynamic membrane areas such as leading edges and ruffling membranes.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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