Thermo Fisher Scientific Phospho-PrP (Ser43) Polyclonal Antibody
Prion 단백질 Ser43 인산화 부위를 인식하는 Rabbit Polyclonal 항체. Western blot에 적합하며 Human, Mouse, Rat 시료에서 반응. 항원 친화 크로마토그래피로 정제. -20°C 보관, 동결/해동 반복 피할 것.
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Applications
- Western Blot (WB): 1:1,000 dilution
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Phospho-peptide including amino acids surrounding Serine 43 in human prion protein; conserved in rat, mouse, and bovine PrP |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS with 1 mg/mL BSA, 50% glycerol |
| Contains | 0.05% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2942979 |
Product Specific Information
This antibody detects human recombinant prion protein after phosphorylation by the Cdk5/p25 complex. It may also detect aggregated forms of prion in human PC3 cells treated with Calyculin A.
Target Information
Human prion protein (PrP, also known as PRNP) is a GPI-anchored cell surface glycoprotein associated with lipid rafts and functions as a signaling molecule. PrP plays roles in apoptosis, epithelial cell proliferation, and junction-associated protein distribution in enterocytes. Conversion of normal PrPc to abnormal PrPSc is a key step in prion neurodegenerative disorders such as Creutzfeldt-Jakob disease (CJD). PrPc is rich in alpha-helices, whereas PrPSc has higher beta-sheet content and is resistant to proteinase K.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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