Thermo Fisher Scientific Estrogen Receptor, alpha (Marker of Estrogen Dependence) Recombinant Rabbit Monoclonal Antibody (ESR1/7444R)
Recombinant rabbit monoclonal antibody targeting Estrogen Receptor alpha (ESR1). Suitable for IHC applications in human samples. High purity (Protein A/G) and stable liquid form. Ideal for studying estrogen dependence and receptor signaling pathways.
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Applications
Immunohistochemistry (Paraffin) (IHC (P))
- Assay-dependent
Immunohistochemistry (PFA fixed) (IHC (PFA))
- 1–2 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG, kappa |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | ESR1/7444R |
| Immunogen | Recombinant fragment (around aa495–595) of human ER alpha protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4, with 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | 4°C, do not freeze |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Estrogen Receptors (ER) are members of the steroid/thyroid hormone receptor superfamily of nuclear receptors. The estrogen receptor is a ligand-activated transcription factor that, upon binding estrogen, undergoes a conformational change enabling dimerization and DNA binding to estrogen response elements (ERE). ER regulates gene transcription positively or negatively through coactivator or corepressor recruitment.
There are two main forms of the estrogen receptor—alpha and beta—encoded by separate genes (ESR1 and ESR2). Alternative RNA splicing produces at least four alpha isoforms (66, 53, 47, and 35 kDa). Estrogen receptors are expressed in various tissues and play critical roles in sexual development, reproductive function, and bone physiology. They are also implicated in diseases such as breast cancer, endometrial cancer, and osteoporosis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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