Thermo Fisher Scientific Estrogen Receptor, alpha (Marker of Estrogen Dependence) Recombinant Rabbit Monoclonal Antibody (ESR1/6811R)
Recombinant rabbit monoclonal antibody targeting Estrogen Receptor alpha (ESR1). Validated for WB and IHC applications. High specificity and purity (Protein A/G). Supplied as liquid at 200 µg/mL, ideal for estrogen-dependence studies in human samples.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1–2 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | Assay-dependent |
| Immunohistochemistry (PFA fixed) (IHC (PFA)) | 1–2 µg/mL |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG, kappa |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | ESR1/6811R |
| Immunogen | Recombinant fragment corresponding to C-terminus of human ER-alpha |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4, with 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | 4°C, do not freeze |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Estrogen Receptors (ER) are members of the steroid/thyroid hormone receptor superfamily of nuclear receptors. The estrogen receptor is a ligand-activated transcription factor that, when bound to estrogen, undergoes a conformational change enabling dimerization and binding to estrogen response elements (ERE) in DNA. This binding regulates gene transcription through coactivator or corepressor interactions.
There are two forms of estrogen receptors, alpha and beta, encoded by separate genes (ESR1 and ESR2). Alternative RNA splicing produces at least four ER-alpha isoforms (66 kDa, 53 kDa, 47 kDa, and 35 kDa). Estrogen receptors are widely expressed and are essential for sexual development, reproductive function, and bone maintenance. They are implicated in pathological processes including breast cancer, endometrial cancer, and osteoporosis.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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