Thermo Fisher Scientific Trop2 (EGP-1) Monoclonal Antibody (MR54), eBioscience
인간 Trop-2(TACSTD2, EGP-1) 단백질을 인식하는 MR54 클론의 마우스 단클론 항체로, 다양한 암세포 및 상피세포에서 발현되는 종양 관련 칼슘 신호 전달 단백질 검출에 사용. WB, IHC-P, ICC, Flow, ELISA, IP 등 다양한 응용에 적합. 고순도(>90%) 및 0.2 µm 여과 처리됨.
- 카탈로그번호
- 14-6024-82
- 판매단위
- pk
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Thermo Fisher Scientific Trop2 (EGP-1) Monoclonal Antibody (MR54), eBioscience
Applications and Tested Dilution
| Application | Tested Dilution | Notes |
|---|---|---|
| Western Blot (WB) | Assay-Dependent | |
| Immunohistochemistry (Paraffin) (IHC-P) | 5 µg/mL | |
| Immunocytochemistry (ICC/IF) | 5 µg/mL | |
| Flow Cytometry (Flow) | Assay-Dependent | |
| ELISA | Assay-Dependent | |
| Immunoprecipitation (IP) | Assay-Dependent |
Product Specifications
| Specification | Detail |
|---|---|
| Species Reactivity | Human |
| Published Species | Human |
| Host / Isotype | Mouse / IgG2a, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | MR54 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.2 |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_10853488 |
Additional Formats
- Alexa Fluor 488 conjugate (53-6024-82)
- PE conjugate (12-6024-42)
- Request custom conjugation
Product Specific Information
This MR54 monoclonal antibody reacts with human Trop-2 (Tumor-Associated Calcium Signal Transducer 2, TACSTD2, EGP-1).
Trop-2 is a type I transmembrane glycoprotein expressed on trophoblasts, epithelial cells, and most human carcinoma cells, playing a role in calcium-mediated signaling.
It has been reported as an oncogene correlated with tumorigenesis, metastasis, and anchorage-independent growth.
Applications Reported: Flow cytometry, immunoprecipitation, western blotting, immunohistochemistry (FFPE tissue, IHC-P), ELISA, and immunocytochemistry (ICC).
Applications Tested: Tested on MCF7 cells and FFPE tissues using low or high pH antigen retrieval; high pH provides better staining intensity. Recommended ≤5 µg/mL and titration for optimal performance.
Purity: >90% (SDS-PAGE)
Aggregation: <10% (HPLC)
Filtration: 0.2 µm post-manufacturing filtered
Target Information
TROP2 is a carcinoma-associated antigen defined by the monoclonal antibody GA733.
It belongs to a family of type I membrane proteins that transduce intracellular calcium signals and act as cell surface receptors.
Mutations in the TROP2 gene cause gelatinous drop-like corneal dystrophy, an autosomal recessive disorder characterized by severe corneal amyloidosis leading to blindness.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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