Thermo Fisher Scientific MOV10 Polyclonal Antibody
MOV10 단백질을 인식하는 Rabbit Polyclonal 항체로, Western blot 및 Immunoprecipitation에 적합합니다. 인간 MOV10의 953-1003 잔기 영역을 면역원으로 사용하며, 액상 형태로 1 mg/mL 농도 제공합니다. 연구용으로만 사용 가능합니다.
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Applications
Western Blot (WB)
- Tested Dilution: 1:2,000–1:10,000
Immunoprecipitation (IP)
- Tested Dilution: 2–5 µg/mg lysate
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 953 and 1003 of human Moloney leukemia virus 10 homolog |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
- Recommended shelf life: 1 year from date of receipt
- Based on 100% sequence identity, this antibody is predicted to react with Bovine.
Target Information
MOV10 is a 5′ to 3′ RNA helicase contributing to UPF1 mRNA target degradation by translocation along 3′ UTRs. It is required for microRNA (miRNA)-mediated gene silencing by the RNA-induced silencing complex (RISC), including both translational repression and cleavage of complementary mRNAs.
In cooperation with FMR1, MOV10 regulates miRNA-mediated translational repression by AGO2 and restricts retrotransposition of LINE-1 elements with TUT4 and TUT7. It facilitates LINE-1 uridylation and is essential for embryonic viability and normal CNS development.
MOV10 suppresses retroelements in the nucleus and regulates cytoskeletal mRNAs in the cytosol, influencing neurite outgrowth. It may function as an mRNP clearance factor and exhibits antiviral activity against dengue virus (DENV).
[UniProt]
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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