Thermo Fisher Scientific Estrogen Receptor alpha Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Target Information

Estrogen Receptors (ER) are members of the steroid/thyroid hormone receptor superfamily of nuclear receptors. The estrogen receptor is a ligand-activated transcription factor that, when bound to estrogen hormone, induces a conformational change enabling dimerization and binding to estrogen response elements (ERE) in DNA. This binding allows ER to regulate gene transcription through coactivator or corepressor proteins.

There are two forms of the estrogen receptor, alpha and beta, encoded by ESR1 and ESR2 genes, respectively. Due to alternative RNA splicing, at least four estrogen receptor-alpha isoforms exist (Isoform 1: 66 kDa, Isoform 2: 53 kDa, Isoform 3: 47 kDa, Isoform 4: 35 kDa). Estrogen receptors are expressed in various tissues, essential for sexual development and reproductive function, and play roles in bone and other tissues. They are also involved in pathological processes such as breast cancer, endometrial cancer, and osteoporosis.

For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.