Thermo Fisher Scientific Estrogen Receptor alpha Polyclonal Antibody
Western blot, IHC, ELISA, IP에 적합한 다중 응용 항체. 사람, 마우스, 랫드 등 다양한 종에 반응. 합성 펩타이드 기반 Rabbit Polyclonal 항체로, 고순도 친화 크로마토그래피 정제. -20°C 보관, 연구용 전용.
- 카탈로그번호
- ESTRA-121AP
- 판매단위
- pk
카탈로그
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunohistochemistry (IHC) | 1:50–1:250 |
| ELISA | 1:10,000 |
| Immunoprecipitation (IP) | 1:50–1:250 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Non-human primate, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide within amino acid region 545–595 on human Estrogen receptor alpha protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5–1.5 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | Proprietary buffer, pH 7.4–7.8, with 30% glycerol, 0.5% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | –20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Estrogen Receptors (ER) are members of the steroid/thyroid hormone receptor superfamily of nuclear receptors. The estrogen receptor is a ligand-activated transcription factor that, when bound to estrogen hormone, induces a conformational change enabling dimerization and binding to estrogen response elements (ERE) in DNA. This binding allows ER to regulate gene transcription through coactivator or corepressor proteins.
There are two forms of the estrogen receptor, alpha and beta, encoded by ESR1 and ESR2 genes, respectively. Due to alternative RNA splicing, at least four estrogen receptor-alpha isoforms exist (Isoform 1: 66 kDa, Isoform 2: 53 kDa, Isoform 3: 47 kDa, Isoform 4: 35 kDa). Estrogen receptors are expressed in various tissues, essential for sexual development and reproductive function, and play roles in bone and other tissues. They are also involved in pathological processes such as breast cancer, endometrial cancer, and osteoporosis.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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