Thermo Fisher Scientific OASL Polyclonal Antibody
Human OASL 단백질을 인식하는 Rabbit Polyclonal Antibody로 Western blot 및 IHC에 적합. 항원 친화 크로마토그래피로 정제된 액상 형태, 1 mg/mL 농도. HeLa, HepG2, HCT116 세포에서 양성 대조군으로 추천. 연구용으로만 사용 가능.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:3,000
- View 1 publication
Immunohistochemistry (IHC)
- Tested Dilution: –
- View 1 publication
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Published Species | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fragment corresponding to a region within amino acids 1–274 of Human OASL (UniProt ID: Q15646-1) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7 |
| Contains | No preservative |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2548791 |
Product Specific Information
- Recommended positive controls: HeLa, HepG2, HCT116
- Predicted reactivity: Chimpanzee (98%)
- Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
2-prime,5-prime oligoadenylates (2-5As) bind to and activate RNase L, leading to degradation of RNA and inhibition of protein synthesis.
2-5As are produced by 2-5A synthetases (OASs), a highly conserved family of interferon-induced enzymes.
The predicted 514-amino acid human p59OASL (2-5A synthetases-like) protein shares a highly conserved N-terminal domain with other OASs.
The C-terminal portion of p59OASL contains two ubiquitin-like domains.
p59OASL is expressed in most tissues, with the highest levels in hematopoietic tissues, colon, and stomach.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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