Thermo Fisher Scientific Phospho-ATF2 (Ser322) Polyclonal Antibody
인간 ATF2 단백질의 Ser322 인산화 부위를 인식하는 Rabbit Polyclonal Antibody. Dot blot에 최적화되어 있으며, Protein A 및 항원 친화 크로마토그래피로 정제됨. PBS 버퍼에 0.09% sodium azide 포함, 4°C 또는 -20°C 보관 권장.
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Applications
- Dot blot (DB)
Tested Dilution: 1:500
Publications: 없음
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S322 of human ATF2 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification | Protein A, Antigen affinity chromatography |
| Storage buffer | PBS, pH 7.4 |
| Contains | 0.09% sodium azide |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_10987950 |
Target Information
The transcription factor ATF-2 (also called CRE-BP1) binds to both AP-1 and CRE DNA response elements and is a member of the ATF/CREB family of leucine zipper proteins.
ATF-2 interacts with various viral oncoproteins and cellular tumor suppressors and is a target of the SAPK/JNK and p38 MAP kinase signaling pathways.
Cellular stress such as genotoxic agents, inflammatory cytokines, and UV irradiation stimulate ATF-2 transcriptional activity.
Activation occurs via phosphorylation of Thr69 and Thr71, mediated by SAPK and p38 MAPK both in vitro and in transfected cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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