Thermo Fisher Scientific Phospho-VPS34 (Ser676) Polyclonal Antibody
Phospho-VPS34 (Ser676) 폴리클로날 항체로 인간 VPS34의 S676 부위 인산화 형태를 검출. Western blot 및 Dot blot에 사용 가능. Protein A 및 항원 친화 크로마토그래피로 정제됨. PBS buffer에 0.09% sodium azide 포함. 연구용으로만 사용.
- 카탈로그번호
- PA512799
- 판매단위
- pk
카탈로그
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Applications
Western Blot (WB)
- Assay-dependent
- View 2 publications
Dot Blot (DB)
- 1:500
- View references
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Published Species | Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH-conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S676 of human PI3KC3 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Protein A, Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.4 |
| Contains | 0.09% sodium azide |
| Storage Conditions | Store at 4°C short term; for long-term storage, store at -20°C, avoiding freeze/thaw cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2165122 |
Product Specific Information
This antibody is predicted to react with mouse, porcine, rat, and Xenopus based on sequence homology.
Target Information
PIK3C3 (hVPS34) is the sole class III member of the PI3 Kinase family. It phosphorylates phosphatidylinositol (PI) to produce phosphatidylinositol 3-phosphate [PI(3)P], which recruits downstream effectors containing FYVE and Phox domains to membranes.
PIK3C3 is involved in coupling nutrient signaling to mTOR and plays a role in autophagy and intracellular trafficking. It regulates degradative endocytic trafficking and is required for the abscission step in cytokinesis, likely in the context of PI3KC3-C2. It also contributes to the transport of lysosomal enzyme precursors to lysosomes and is essential for transport from early to late endosomes.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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