Thermo Fisher Scientific CaMKII alpha Polyclonal Antibody
Rabbit polyclonal antibody targeting CaMKII alpha for WB and IHC applications. Recognizes human, mouse, and rat proteins. High purity (>95%) and affinity-purified. Supplied as liquid, unconjugated, 1 mg/mL in PBS with glycerol. Ideal for studying neuro...
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Thermo Fisher Scientific CaMKII alpha Polyclonal Antibody
Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
Product Specifications
| Property | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to amino acids 260–310 of Human CaMKII alpha |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term; for long-term storage, store at -20°C, avoiding freeze/thaw cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2803438 |
Product Specific Information
Purity is >95% by SDS-PAGE.
Target Information
CAMK2A (CaMKII alpha) is a serine/threonine kinase that regulates various cellular functions, including neuronal processes, gene expression, carbohydrate metabolism, cytoskeletal organization, and calcium homeostasis.
Autophosphorylation of threonine 286 in the presence of Ca²⁺ and calmodulin activates CAMK2A, enabling a switch from calmodulin-dependent to independent activity.
CaMKII is ubiquitously expressed and plays key roles in dendritic spine and synapse formation, neuronal plasticity, and calcium transport regulation in skeletal muscle. In neurons, it contributes structurally to actin cytoskeleton reorganization during plasticity by binding and bundling actin filaments in a kinase-independent manner.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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