Thermo Fisher Scientific ATM Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:500

Immunohistochemistry (Paraffin) (IHC (P))

• Tested Dilution: 1:50–1:200

Product Specifications

Product Specific Information

• Purity: >95% by SDS-PAGE.

Target Information

Ataxia-telangiectasia Mutated (ATM) is a protein belonging to the PI3/PI4 kinase family.
Ataxia-telangiectasia is a rare autosomal recessive disorder characterized by progressive neurologic degeneration, immunologic deficiency, and an increased risk of lymphoid cancer.
The ATM gene codes for a protein in the phosphoinositide 3-kinase (PI3K) superfamily. ATM phosphorylates proteins rather than lipids and has downstream targets involved in cell-cycle regulation, including P53, Mdm2, BRCA1, and SMC1.
ATM is responsible for repairing double-stranded DNA breaks caused by ionizing radiation and other mutagens. The C-terminal region of ATM shows homology to catalytic domains of PI3 kinases.
ATM becomes autophosphorylated and upregulated upon exposure to ionizing radiation. AT cells are hypersensitive to radiation, show impaired DNA synthesis inhibition, and delayed p53 induction.
DNA damage activates ATM-kinase, triggering kinase cascades regulating cell cycle, apoptosis, and DNA damage repair.
ATM is linked to apoptosis along with Nbs1 and Chk2 in the E2F1 pathway.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.