Thermo Fisher Scientific SOCS3 Monoclonal Antibody (OTI5D4), TrueMAB

Applications and Tested Dilution

Product Specifications

Product Specific Information

For reconstitution, add 100 µL distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments using this carrier-free antibody, perform an additional desalting step using Zeba Spin Desalting Columns (7K MWCO, 0.5 mL, Product #89882).

Target Information

SOCS (Suppressor of Cytokine Signaling) proteins negatively regulate cytokine receptor signaling. Eight members of the SOCS family have been identified: SOCS-1, 2, 3, 4, 5, 6, 7, and CIS.
These proteins contain an N-terminal variable region, a central SH2 domain, and a C-terminal SOCS box motif.
SOCS proteins participate in a negative feedback loop regulating cytokine signal transduction via STAT-induced transcription.
Transcription of SOCS genes occurs rapidly in response to cytokines, and each member inhibits signaling through distinct mechanisms.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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