Thermo Fisher Scientific ADAM10 Monoclonal Antibody (139712)
ADAM10 단백질을 인식하는 Rat IgG2a 단일클론 항체로, Western blot 및 유세포 분석에 적합합니다. 마우스 시료 반응성이 있으며, 단백질 A/G로 정제된 동결건조 형태입니다. PBS와 5% 트레할로스 완충액에 보관하며, -20°C에서 보존합니다.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1 µg/mL |
| Flow Cytometry (Flow) | 2.5 µg per million cells |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Mouse |
| Host / Isotype | Rat / IgG2a |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 139712 |
| Immunogen | Sf21-derived recombinant mouse ADAM10 (Thr215–Glu673) |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 0.5 mg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS with 5% trehalose |
| Contains | No Preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2610315 |
Product Specific Information
- In direct ELISAs, approximately 25% cross-reactivity with recombinant human ADAM10 is observed.
- No cross-reactivity with rhADAM8, rmADAM9, rmADAM15, rhBACE, or rhTACE.
- Reconstitute at 0.5 mg/mL in sterile PBS.
Target Information
Proinflammatory cytokine TNF-α contributes to inflammatory responses and programmed cell death.
The Notch receptor and its ligand participate in cell fate decisions during vertebrate development and are associated with several human disorders, including T-cell lymphoma.
TNF-α, Notch, and its ligand Delta are membrane-bound molecules cleaved by proteases to release mature or functional proteins.
ADAM10, a metalloprotease-disintegrin in the ADAM family, cleaves TNF-α, Notch, and Delta.
Human, mouse, and bovine ADAM10 genes have been cloned and designated ADAM10, KUZ (kuzbanian), and MADM, respectively.
ADAM10 mRNA is expressed in various human and bovine tissues.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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