Thermo Fisher Scientific TPSB2 Monoclonal Antibody (349414)

Applications

Tested Dilution

Publications

Western Blot (WB)

1 µg/mL

-

Immunoprecipitation (IP)

25 µg/mL

-

Neutralization (Neu)

1.4 µg/mL

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Mouse / IgG1

Class

Monoclonal

Type

Antibody

Clone

349414

Immunogen

Mouse myeloma cell line NS0-derived recombinant human Tryptase beta-2/TPSB2 Ile31-Pro275 if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:TPSB2,uniProtId:P20231-1,ncbiNodeId:9606,antigenRange:31-275,antigenLength:275,antigenImageFileName:MA5-24091_TPSB2_P20231-1_House_mouse.svg,antigenImageFileNamePDP:MA5-24091_TPSB2_P20231-1_House_mouse_PDP.jpeg,sortOrder:2}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Lyophilized

Concentration

0.5 mg/mL

Purification

Protein A/G

Storage buffer

PBS with 5% trehalose

Contains

No Preservative

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2609250

Product Specific Information

In direct ELISAs and Western blots, no cross-reactivity with recombinant human (rh) TPS1, rhTPSG1, recombinant mouse (rm) TPS5, rmMCPT1, rmMCPT6, rmMCPT7, or rmMCPT11 is observed.

Reconstitute at 0.5 mg/mL in sterile PBS.

Target Information

TPSB2 is a protein coding gene. Tryptases comprise a family of trypsin-like serine proteases, the peptidase family S1. Tryptases are enzymatically active only as heparin-stabilized tetramers, and they are resistant to all known endogenous proteinase inhibitors. Several tryptase genes are clustered on chromosome 16p13.3. These genes are characterized by several distinct features. They have a highly conserved 3UTR and contain tandem repeat sequences at the 5 flank and 3` UTR which are thought to play a role in regulation of the mRNA stability. These genes have an intron immediately upstream of the initiator Met codon, which separates the site of transcription initiation from protein coding sequence. This feature is characteristic of tryptases but is unusual in other genes. The alleles of this gene exhibit an unusual amount of sequence variation, such that the alleles were once thought to represent two separate genes, beta II and beta III. Beta tryptases appear to be the main isoenzymes expressed in mast cells, whereas in basophils, alpha-tryptases predominate. Tryptases have been implicated as mediators in the pathogenesis of asthma and other allergic and inflammatory disorders.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.