Thermo Fisher Scientific STK38 Monoclonal Antibody (2F6)
STK38 단백질을 인식하는 Thermo Fisher Scientific의 단클론 항체로, Western blot 및 ELISA에 적합합니다. Human 시료 반응성이 있으며 Mouse IgG1, kappa 형식입니다. 비결합(Unconjugated) 상태의 액상 제품으로, 연구용으로만 사용됩니다.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| ELISA | 10 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 2F6 |
| Immunogen | STK38 (AAH12085, 365–465 a.a.) partial recombinant protein with GST tag (GST tag MW: 26 kDa) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | See Label |
| Storage Buffer | Ascites |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Sequence of this protein is as follows:
EHRIGAPGVE EIKSNSFFEG VDWEHIRERP AAISIEIKSI DDTSNFDEFP ESDILKPTVA TSNHPETDYK NKDWVFINYT YKRFEGLTAR GAIPSYMKAA K
Target Information
STK38 (also known as NDR, Nuclear Dbf2-related protein) is a serine/threonine kinase belonging to the AGC kinase family regulated by Mob proteins.
Fas and TNFα receptor stimulation activates human STK38 by promoting phosphorylation at the hydrophobic motif.
NDR acts as a novel pro-apoptotic kinase and is a key member of the RASSF1A/MST1 signaling cascade.
STK38 is crucial for mitotic chromosome alignment fidelity in mammalian cells and is incorporated into HIV-1 particles where it is cleaved by the HIV-1 protease.
STK38-driven centrosome duplication requires Cdk2 activity, and Cdk2-induced centrosome amplification is affected when STK38 activity is reduced.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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